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עמוד:*6
6 * - The acknowledged health outcomes of frequent consumption of processed - food ( the modern mal . ) 13 ( nutrition ) include obesity and numerous metabolic disorders ( 14 ) . In our recent study, we fed young growing rats with ultra - processed - food and studied its effect on bone development and quality . Rats fed with this diet demonstrated severe bone phenotypes, including cartilaginous lesions in their growth - plates and a sieve - like appearance of the cortical bone . This was accompanied by significant reduction in bone mineral density and reduced mechanical strength to less than half compared to healthy bones ( Figure 1 ) . The data highlights a serious implication of ultra - processed - diets during childhood, novel phenotypes which are way beyond the known metabolic effects of such diet . Figure 1 │ Calcium supplementation of fast - food diet rescues tibial GPstructure but results in kidney mineralization . rats were divided randomly into 3 groups . The 1 st group ( n = 8 ) got a standard diet ( Control ) . The 2 nd group ( n = 8 ) was given 24 a diet based fast - food including soft drink ( FF + CSD ) . The 3 rd group ( n = 8 ) received the fast - food diet supplemented with calcium phosphate ( FF + CSD + Ca ) . At the end of the experiment, rats were anesthetized with isofluran, blood samples were collected, and the animals were sacrificed . Their internal organs ( kidney ) and bones ( femur, tibia ) were harvested . a, Total of 12 tibiae were dissected, processed and stained with safranin - O . b, Representative 3 - D reconstructions of whole femur scaled for mineral density . d, Staining of tibial GP for ALPand TRAP activity . e, Total of 16 kidneys were dissected, processed and stained with Alcian von Kossa staining, detecting mineral deposits .
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אדמוני, אריאל
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