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עמוד:*7
7 * Based on our expertise in diet planning and bone analyses, we developed a sensitive physiological preclinical model that can rapidly and confidently address the health issue of different nutrients and diet patterns . Our model is based on the postnatal growth, defined as the gain in body size during the juvenile period . Postnatal skeleton growth is the major parameter for development and health in children, and heavily influenced by consumption of various compounds during the period of rapid growth . Thus, the young rat provides a most sensitive and reliable preclinical model to study minute variation in the diet and observe the quality of the diet . For instance, in one of our projects we assess the health implication of alternative proteins in the diet . A growing global population place increased pressure on the world’s resources to provide sustainable and healthy food . Particularly, animal - based protein has a negative environmental impact on gas emissions water and land resources . Thus, conjoining alternative protein sources in the human diet, such as algae, bugs or "artificial meat", is a major challenge, that requires comparisons between novel and existing proteins, in terms of health impacts . We are using this preclinical model to address the effect of different protein sources in the diet on growth, physiology and quality parameters of the skeleton . The alternative protein sources that tested in equivalent diets are : animal, plant, insects, algae and in - vitro meat . The combined deep understanding and expertise of our lab in diet planning and bone biology, together with the use of gene expression studies ( transcriptome ) , microbiome analyses and computational data mining approach, enable the optimization of future protein alternatives in the diet Figure 2 ) . ( Figure 2 | Graphical illustration of the experimental platform and time line of the pre - clinical model and the analyses that will be performed during the experiment and subsequently .
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אדמוני, אריאל
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